Assessing the Burden of Hepatitis C Virus Related Liver Diseases in the U.S. Birth Cohort


This project uses commercial lab data to evaluate different aspects of the burden of liver disease among persons with HCV in the United States. The most recent analysis showed that during 2010–2013, a total of 273,143 persons had a first positive HCV-RNA test result and known date of birth. Of these, 186,416 (68.2 percent) were born from 1945–1965. For all years combined, most persons in the birth cohort had moderate fibrosis (42.3 percent) followed by severe fibrosis (28.7 percent) and cirrhosis (22.7 percent). Almost no variation was found over the four-year period by stage of FIB–4. In 2013, 53.1 percent of persons born from 1945–1965 had severe fibrosis or cirrhosis. This proportion was higher than among individuals born after 1965 (12.4 percent), but lower than among individuals born before 1945 (79.7 percent). These results indicate an alarming rate of severe fibrosis or cirrhosis in individuals born between and 1945–1965. Improved screening for HCV and linkage to recommended care and treatment are urgently needed to prevent complications in this population.

An abstract on this analysis was accepted for oral presentation at the Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle, February 23–26, 2015. 

Quest Diagnostics provided support for this project through an in-kind data sharing agreement with CDC. The project is also supported by funds from AbbVie.